Evidence supporting the use of: 5-HTP
For the body system: Pineal Gland

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin and melatonin. The pineal gland is chiefly responsible for the production of melatonin, a hormone that regulates sleep-wake cycles. Scientifically, 5-HTP is used to increase serotonin levels in the brain, and since serotonin is a direct precursor to melatonin, supplementation with 5-HTP is hypothesized to support the pineal gland’s function in melatonin synthesis. There is some research indicating that 5-HTP supplementation can modestly increase melatonin levels, especially in individuals with low serotonin or disrupted sleep patterns. However, most of the evidence comes from small clinical studies, and the direct effect of 5-HTP on pineal gland health or function is not robustly established. The majority of studies focus on 5-HTP’s role in mood regulation, depression, and sleep, with only indirect implications for pineal gland support. Thus, while there is a plausible biochemical pathway linking 5-HTP to melatonin production in the pineal gland, the evidence base is limited and rated as moderate to low. More high-quality, direct research is needed to validate routine use of 5-HTP for explicit support of pineal gland health and function.

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Products containing 5-HTP

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