Evidence supporting the use of: 5-HTP (test)
For the body system: Pineal Gland

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin and melatonin, both of which are closely associated with pineal gland function. The pineal gland is responsible for the production of melatonin, a hormone that regulates sleep-wake cycles and circadian rhythms. Scientific studies have shown that 5-HTP supplementation can increase serotonin levels in the brain, and since serotonin is converted to melatonin in the pineal gland, it is hypothesized that 5-HTP could support pineal gland activity indirectly by enhancing melatonin production. Several clinical trials have investigated 5-HTP’s effects on sleep and mood, with some showing modest improvements in sleep quality, likely due to increased melatonin synthesis. However, direct evidence linking 5-HTP supplementation specifically to improved pineal gland health or function is limited. Most research focuses on downstream effects (such as sleep regulation or mood enhancement) rather than direct pineal gland support. Nevertheless, the mechanism is biologically plausible and there is a moderate amount of scientific interest in 5-HTP’s role in supporting melatonin production via the pineal gland. In summary, there is scientific rationale and some supporting evidence for the use of 5-HTP to support functions related to the pineal gland, particularly melatonin production, but direct clinical validation for pineal gland support is not robust.

More about 5-HTP (test)
More about Pineal Gland

Other body systems supported by 5-HTP (test)

Brain
Glandular System
Pineal Gland
Serotonin
Specific Neurotransmitters

Products containing 5-HTP (test)

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