Evidence supporting the use of: Agnuside
For the body system: Pituitary

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Agnuside is an iridoid glycoside found predominantly in the fruit of Vitex agnus-castus (chaste tree). Its use in supporting the pituitary body system is primarily rooted in traditional herbal medicine. Historically, Vitex agnus-castus has been used for centuries in European and Mediterranean herbal traditions to manage various gynecological conditions, such as premenstrual syndrome (PMS), menstrual irregularities, and infertility. The rationale for its use is based on the belief that compounds within the plant, including agnuside, can influence hormonal balance by acting on the hypothalamic-pituitary axis, thus affecting prolactin secretion and other aspects of pituitary function.

While there is some preliminary scientific research suggesting that extracts of Vitex agnus-castus may have dopaminergic effects that can suppress prolactin release, most of the studies focus on the whole extract rather than isolated agnuside. Direct scientific evidence supporting agnuside alone as a modulator of pituitary function is limited. The evidence for the use of agnuside to support the pituitary system specifically remains largely traditional, with scientific validation being modest and mostly indirect through studies of the whole plant extract. Therefore, the justification for using agnuside for pituitary support is best described as traditional with some emerging but not conclusive scientific support.

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