Evidence supporting the use of: Chaste tree
For the body system: Pituitary

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chaste tree (Vitex agnus-castus), also known as chasteberry, has a longstanding traditional use for supporting women’s reproductive health, particularly in managing symptoms of premenstrual syndrome (PMS), menstrual irregularities, and mild hyperprolactinemia. Modern scientific research has provided some validation for these effects, most notably its impact on the pituitary gland’s secretion of prolactin. The primary bioactive constituents in chaste tree appear to interact with dopamine receptors, leading to a reduction in prolactin release from the anterior pituitary. Clinical studies have shown that supplementation with chaste tree extract can normalize prolactin levels and improve symptoms associated with elevated prolactin, such as irregular cycles and premenstrual symptoms (van Die et al., 2003).

While the evidence is strongest for its effect on prolactin and menstrual-related complaints, there is limited but supportive data that chaste tree can beneficially modulate pituitary function. However, its effects are not broad-spectrum for all pituitary hormones; its influence is primarily restricted to prolactin. The European Medicines Agency recognizes chaste tree for the relief of minor PMS symptoms, and several double-blind placebo-controlled trials support its efficacy. Still, more research is needed to fully elucidate its broader role in pituitary regulation beyond prolactin suppression.

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