Evidence supporting the use of: Agnusides
For the body system: Pituitary (anterior)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Agnusides are the primary active iridoid glycosides found in the fruit of Vitex agnus-castus (chaste tree). The use of Vitex for supporting the anterior pituitary (adenohypophysis) is supported by both traditional herbal medicine and modern scientific investigations, though the evidence is moderate rather than robust. Scientific studies indicate that agnusides and related compounds in Vitex can influence pituitary hormone secretion, particularly by modulating prolactin levels. This is thought to occur via dopaminergic effects, as Vitex extracts have demonstrated the ability to bind dopamine receptors, thus inhibiting prolactin release from the anterior pituitary. Clinical trials have shown efficacy in conditions linked to pituitary hormone imbalance such as premenstrual syndrome (PMS) and mastalgia, where abnormal prolactin is implicated. However, while the evidence suggests a meaningful effect on anterior pituitary function through prolactin modulation, the impact on other pituitary hormones (e.g., LH, FSH, ACTH) is less clear and not as well documented. Most studies use whole plant extracts rather than isolated agnusides, and there is a need for more research focused specifically on agnusides and broader pituitary function. In summary, the use of agnusides to support anterior pituitary health is scientifically plausible and supported by moderate clinical evidence, but more targeted research is warranted.

More about Agnusides
More about Pituitary (anterior)

Other ingredients that support Pituitary (anterior)

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hypothalamus
Agnuside
D-Aspartic Acid

Products containing Agnusides

We currently have no products on Vitabase that contain this ingredient.