Evidence supporting the use of: Chastetree
For the body system: Pituitary (anterior)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chastetree (Vitex agnus-castus), also known as chasteberry, has a long history of traditional use for supporting reproductive health, particularly in women. More recently, its use has been investigated with a scientific lens. The primary justification for using chasteberry to support the anterior pituitary lies in its effects on the hypothalamic-pituitary axis. Several clinical and preclinical studies suggest that compounds in chasteberry can influence the secretion of prolactin by acting on dopamine receptors in the pituitary gland. Elevated prolactin, often due to subtle disturbances in pituitary function, can cause menstrual irregularities and other reproductive issues. Chastetree extracts have been shown in randomized controlled trials to reduce mild hyperprolactinemia and alleviate symptoms of premenstrual syndrome (PMS), thought to be mediated via dopaminergic modulation at the level of the anterior pituitary.

While chasteberry is not a direct "pituitary tonic," the scientific evidence supports its role in modulating anterior pituitary hormone secretion, particularly prolactin. Reviews and clinical studies (e.g., JAMA 2001; BMJ 2012) generally conclude that chasteberry is more effective than placebo for PMS and related symptoms, likely by impacting pituitary hormone balance. However, evidence is strongest for mild cases and menstrual complaints, and less robust for broader pituitary health. Thus, the evidence rating is a 3: there is scientific support, but it is moderate and specific to certain hormonal pathways rather than general "pituitary support."

More about Chastetree
More about Pituitary (anterior)

Other ingredients that support Pituitary (anterior)

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l-arginine
hypothalamus
Agnuside
D-Aspartic Acid

Products containing Chastetree

We currently have no products on Vitabase that contain this ingredient.