Evidence supporting the use of: D-Aspartic Acid
For the body system: Pituitary (anterior)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
D-Aspartic Acid (DAA) is a naturally occurring amino acid that has garnered interest for its potential role in supporting the anterior pituitary, particularly in stimulating the release of luteinizing hormone (LH) and, subsequently, testosterone production. Scientific studies in animals and humans have shown that DAA can transiently increase LH and testosterone levels, which are regulated by the anterior pituitary. A pivotal human study (Topo et al., 2009) found that 12 days of DAA supplementation led to increased LH and testosterone in healthy men; however, the effect appeared to plateau or diminish with prolonged use, and results have been inconsistent across subsequent studies. Some research in athletes and resistance-trained men found no significant hormonal effects, and the overall impact on anterior pituitary function beyond LH stimulation is not well established.
Traditional use of DAA specifically for pituitary support is not documented in herbal medicine or historical texts; its use is based on modern biochemical understanding. The primary scientific rationale for DAA is its role as an endogenous regulator of neuroendocrine function, particularly in the hypothalamic-pituitary-gonadal axis. However, the evidence for meaningful or sustained support of anterior pituitary function is limited, and there are no long-term safety or efficacy data. Thus, while there is some scientific evidence for short-term LH stimulation via pituitary activation, the overall strength of the evidence is modest, justifying a rating of 2 out of 5.
Other ingredients that support Pituitary (anterior)
alfalfaashwagandha
bovine
l-arginine
hypothalamus
Agnuside
D-Aspartic Acid
Other body systems supported by D-Aspartic Acid
HypothalamusMale Reproductive System
Pituitary (anterior)
Specific Neurotransmitters
Testes
Testosterone