Evidence supporting the use of: MK-677
For the body system: Pituitary (anterior)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

MK-677 (also known as Ibutamoren) is primarily supported by scientific evidence for its effects on the anterior pituitary body system. MK-677 is a non-peptide, orally active growth hormone secretagogue that mimics the action of ghrelin. It binds to the ghrelin receptor (GHSR) in the brain, which stimulates the release of growth hormone (GH) from the anterior pituitary gland. Multiple clinical studies have shown that MK-677 increases circulating levels of GH, as well as insulin-like growth factor 1 (IGF-1), in both healthy adults and populations with GH deficiencies.

For example, a pivotal study by Smith et al. (1997, J Clin Endocrinol Metab) demonstrated that daily administration of MK-677 in elderly subjects significantly increased GH and IGF-1 concentrations to levels commonly seen in young adults, without serious adverse effects. Further, other studies have confirmed its efficacy in stimulating the pituitary to secrete more GH, which in turn can impact body composition, bone density, and metabolism. However, while the mechanism and efficacy for stimulating the anterior pituitary are well-documented, the long-term safety and clinical benefits for anti-aging or muscle growth purposes remain under investigation.

Therefore, the use of MK-677 to support the anterior pituitary system is justified by scientific evidence, particularly regarding its ability to stimulate GH release. It is not based on tradition, and its use is not unsupported.

More about MK-677
More about Pituitary (anterior)

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Products containing MK-677

We currently have no products on Vitabase that contain this ingredient.