Evidence supporting the use of: Diindoylmethane
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and kale. Its use for premenstrual syndrome (PMS) is based on its influence on estrogen metabolism. DIM promotes the conversion of estrogen into less potent forms, potentially leading to a healthier estrogen balance. Since PMS symptoms are often related to fluctuations or imbalances in estrogen and progesterone, there is a theoretical rationale for DIM supplementation to help alleviate symptoms such as mood swings, bloating, and breast tenderness.

However, while DIM’s impact on estrogen metabolism is supported by some laboratory and animal studies, direct clinical evidence for its effectiveness in treating PMS in humans is limited. A few small pilot studies and anecdotal reports suggest some women may experience relief in PMS-related symptoms, but robust randomized controlled trials are lacking. Most of the supporting evidence is therefore indirect, extrapolated from DIM’s effect on estrogen pathways rather than specifically on PMS. Clinical guidelines do not currently recommend DIM as a standard treatment for PMS. Thus, while there is a plausible scientific mechanism and early-stage evidence, the overall quality and quantity of research supporting DIM for PMS is low, justifying a modest evidence rating.

More about Diindoylmethane
More about PMS (general)

Products containing Diindoylmethane

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