Evidence supporting the use of: Estrogen
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Estrogen is sometimes used in the management of premenstrual syndrome (PMS), especially in cases where symptoms are severe and do not respond to standard treatments. The rationale for estrogen therapy is based on the observation that hormonal fluctuations, particularly those involving estrogen and progesterone, play a significant role in the pathophysiology of PMS. Scientific studies have shown that suppression of ovulation—thereby stabilizing hormone levels—can reduce PMS symptoms. Estrogen, often administered as transdermal patches or gels, is sometimes used in combination with progestogens to suppress ovulation and stabilize hormonal fluctuations. Clinical trials, such as those using estradiol patches, have demonstrated some efficacy in reducing both physical and psychological symptoms of severe PMS and premenstrual dysphoric disorder (PMDD). However, the evidence is not unequivocal, and treatment is typically reserved for cases where other interventions have failed due to potential risks, such as thromboembolism and endometrial hyperplasia when estrogen is used without adequate progestogen opposition. Systematic reviews and guidelines (e.g., NICE guidelines) acknowledge the use of estrogen for severe PMS/PMDD but emphasize careful patient selection and monitoring. Overall, while there is scientific validation for the use of estrogen in specific, severe cases of PMS, its use is not widespread due to safety concerns and the availability of safer alternatives such as SSRIs or combined oral contraceptives.

More about Estrogen
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Products containing Estrogen

We currently have no products on Vitabase that contain this ingredient.