Guggulsterone is a phytosteroid found in the resin of the Commiphora mukul plant, commonly known as guggul. Its use for premenstrual syndrome (PMS) is primarily rooted in traditional Ayurvedic medicine rather than modern scientific validation. In Ayurveda, guggul has been used for centuries for a variety of conditions, including inflammation, lipid disorders, and as a general "balancing" agent for hormonal health. Some traditional practitioners have recommended guggul-containing preparations for menstrual disorders, including PMS, based on its perceived ability to balance doshas and support reproductive health.

However, there is little to no direct scientific evidence supporting the efficacy of guggulsterone or guggul extracts specifically for PMS symptoms. Most modern research on guggulsterone has focused on its effects on cholesterol metabolism, thyroid function, and anti-inflammatory properties, rather than on gynecological or premenstrual symptoms. Clinical studies targeting PMS as an outcome for guggulsterone or guggul extract are lacking.

In summary, the use of guggulsterone for PMS is based on traditional applications rather than robust scientific research. The evidence from modern clinical studies is minimal or absent, so its use for this purpose should be considered as supported by tradition only, with a low level of evidence.