Evidence supporting the use of: Tree Peony
For the health condition: PMS (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tree Peony (Paeonia suffruticosa) root bark, known as "Mu Dan Pi" in Traditional Chinese Medicine (TCM), has been used for centuries as part of various herbal formulas to address gynecological conditions, including premenstrual syndrome (PMS). Traditionally, it is believed to "cool the blood," move stagnant blood, and regulate menstruation, which aligns with TCM concepts of treating menstrual discomfort and mood disturbances associated with PMS. Tree Peony is often combined with other herbs, notably in the classic formula Xiao Yao San, which is widely prescribed for symptoms such as irritability, mood swings, and abdominal discomfort related to PMS. However, direct scientific evidence supporting Tree Peony's efficacy for PMS is limited. While some studies have investigated the formula Xiao Yao San (which contains Tree Peony among several other herbs) and reported modest improvements in PMS symptoms, it is difficult to isolate the effects of Tree Peony itself. A few pharmacological studies suggest that compounds in Tree Peony may have anti-inflammatory and antispasmodic properties, which could theoretically benefit PMS symptoms, but these findings are preliminary and largely based on animal or in vitro models. Thus, the use of Tree Peony for PMS is justified primarily by traditional use, with only limited scientific exploration and validation to date.

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