Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is commonly used to support or treat symptoms of premenstrual syndrome (PMS). Scientific evidence for its effectiveness is mixed but does exist, warranting some validation for its use. Several randomized controlled trials and meta-analyses have investigated the efficacy of vitamin B6 for PMS, particularly for symptoms such as mood swings, irritability, and bloating. A 1999 meta-analysis (Obstetrics & Gynecology, 1999) concluded that vitamin B6 may be more effective than placebo for overall PMS symptoms, with some benefit noted especially for emotional symptoms. Dosages in studies typically range from 50 to 100 mg daily. However, the quality of the evidence is limited by small sample sizes and methodological differences. More recent systematic reviews acknowledge that while there is some support for vitamin B6, the evidence is not robust and the effect size is modest. The mechanism by which vitamin B6 may help is thought to involve modulation of neurotransmitter synthesis, particularly serotonin, which can influence mood-related PMS symptoms. Major guidelines suggest that vitamin B6 can be considered as a treatment option, but caution is advised regarding potential toxicity at higher doses. Overall, while vitamin B6 is not a definitive or highly effective treatment for PMS, there is scientific precedent for its use, especially for mild to moderate symptoms, supported by moderate-quality evidence.

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