Evidence supporting the use of: Chinese Chastetree
For the health condition: PMS Type A

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Chinese Chastetree (Vitex negundo) is related to the more widely studied Vitex agnus-castus (chaste tree or chasteberry), which has been extensively researched for its effects on premenstrual syndrome (PMS), particularly PMS Type A (characterized by anxiety, irritability, and mood swings). The mechanism is thought to involve modulation of prolactin levels via dopaminergic pathways, which can help rebalance the ratio of estrogen to progesterone and thus alleviate PMS symptoms.

While most clinical trials and pharmacological studies have focused on Vitex agnus-castus, there is emerging, though less robust, evidence for Vitex negundo (Chinese Chastetree). Some studies in animal models and limited human data suggest that extracts of Vitex negundo may possess hormone-modulating, anti-inflammatory, and anxiolytic properties. Traditional use in Chinese and Ayurvedic medicine also supports its application in women's health, including menstrual regulation and alleviation of PMS symptoms.

However, it is important to note that direct, high-quality randomized controlled trials on Vitex negundo for PMS Type A in humans are relatively scarce compared to Vitex agnus-castus. The rating of 4 reflects the strong scientific evidence for the genus as a whole (primarily from V. agnus-castus), with preliminary but promising evidence for V. negundo specifically. Further clinical research is warranted to confirm its efficacy for PMS Type A.

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