Evidence supporting the use of: Vitamin B6 (pyridoxal 5 phosphate)
For the health condition: PMS Type A

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxal 5-phosphate) has been studied for its potential role in alleviating symptoms of premenstrual syndrome (PMS), particularly PMS Type A, which is characterized by anxiety, irritability, and mood swings. The rationale for its use stems from the vitamin's involvement in neurotransmitter synthesis, especially serotonin and dopamine, both of which are implicated in mood regulation. Several clinical trials and meta-analyses have explored the efficacy of vitamin B6 for PMS, with mixed results. Some studies suggest a modest benefit for reducing overall PMS symptoms, particularly mood-related symptoms, while others find no significant effect compared to placebo. The most cited systematic review (Wyatt et al., 1999, BMJ) concluded that vitamin B6 might be beneficial for PMS, but the evidence was limited by methodological weaknesses and small sample sizes. Dosages in studies have ranged from 50 to 100 mg/day, with concerns about potential peripheral neuropathy at higher doses. While vitamin B6 supplementation is not universally endorsed by major medical guidelines, it is sometimes recommended as an option due to its favorable safety profile at moderate doses and the low risk of significant side effects. In summary, there is some scientific support for the use of vitamin B6 in PMS Type A, but the evidence is not robust or consistent enough to warrant a strong recommendation. The evidence rating is modest, reflecting the need for larger, well-designed trials.

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