Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: PMS Type A

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is used to support or treat premenstrual syndrome (PMS) Type A, which is characterized primarily by symptoms of anxiety, irritability, and mood swings. The use of vitamin B6 for PMS is based on the hypothesis that it may influence neurotransmitter synthesis, particularly serotonin and dopamine, which can affect mood and emotional symptoms. Several clinical trials have investigated vitamin B6 for PMS, with mixed results. A 1999 meta-analysis (Wyatt et al., BMJ) concluded that there was some evidence for a beneficial effect of vitamin B6 in reducing PMS symptoms, particularly emotional symptoms, but the quality and size of the trials were limited, and methodological weaknesses were noted. Doses ranged from 50 to 600 mg per day, but concerns about potential neurotoxicity at higher doses exist.

Guidelines and systematic reviews published since then generally conclude that vitamin B6 may offer modest benefit for PMS, especially for mood-related symptoms, but emphasize that the evidence is not robust or consistent. The mechanism is thought to involve B6’s role as a cofactor in neurotransmitter synthesis, but there is no consensus on optimal dosing or duration. Overall, while there is some scientific support, it is not strong, and more high-quality research is needed to confirm efficacy and safety.

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