Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the health condition: PMS Type A

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) is commonly used to support or treat premenstrual syndrome (PMS), particularly PMS Type A, which is characterized by anxiety, irritability, and mood swings. The rationale is based on B6’s role in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation. Several clinical trials and reviews have examined B6’s efficacy for PMS symptoms. A meta-analysis published in the British Journal of Obstetrics and Gynaecology (Wyatt et al., 1999) found some evidence that vitamin B6 at doses up to 100 mg/day may be more effective than placebo for overall PMS symptoms, especially mood-related symptoms. However, the studies included were generally small, heterogeneous, and of variable quality, limiting confidence in the findings. More recent systematic reviews (e.g., Kashanian et al., 2013) conclude that while some benefit is possible, the evidence remains inconclusive due to methodological limitations and inconsistent results. Guidelines from major organizations, such as the American College of Obstetricians and Gynecologists, sometimes mention B6 as a possibly helpful option for mild to moderate PMS symptoms, but emphasize the limited and mixed quality of the evidence. Adverse effects are uncommon at recommended doses, but higher doses may cause neuropathy. In summary, while there is a scientific rationale and some clinical trial evidence for B6 in PMS Type A, the overall quality and consistency of the data are modest, justifying a moderate rating for scientific support.

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