Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS Type C

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) has been studied for its potential role in alleviating symptoms of premenstrual syndrome (PMS), particularly PMS Type C, which is characterized by carbohydrate cravings, headaches, fatigue, and mood changes. The scientific rationale stems from B6’s involvement in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation and appetite control. Several clinical trials and systematic reviews have explored the efficacy of Vitamin B6 supplementation in PMS. A meta-analysis published in the British Journal of Obstetrics and Gynaecology (Wyatt et al., 1999) concluded that Vitamin B6 may be beneficial in reducing overall PMS symptoms, with some studies specifically noting improvements in mood-related and behavioral symptoms. However, the quality of evidence varies, with studies often limited by small sample sizes and methodological differences.

The typical doses studied range from 50 to 100 mg daily, although higher doses are not recommended due to the risk of neurotoxicity. The mechanism by which B6 may help with PMS Type C symptoms is likely related to its role in modulating neurotransmitter synthesis, which can affect mood, cravings, and fatigue. While there is moderate scientific support for Vitamin B6’s efficacy, more rigorous, large-scale trials are needed to confirm these findings and to clarify its specific benefits for PMS Type C symptoms. Overall, current evidence supports a cautious but positive role for Vitamin B6 in the management of PMS, particularly for mood and behavioral symptoms.

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