Evidence supporting the use of: Vitamin B6 (pridoxal 5-phosphate)
For the health condition: PMS Type C

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (in its active form, pyridoxal 5'-phosphate) has been investigated for its potential use in alleviating symptoms of premenstrual syndrome (PMS), including PMS Type C, which is characterized by carbohydrate cravings and symptoms related to fluctuating blood sugar levels. The rationale for using vitamin B6 is primarily based on its role as a coenzyme in neurotransmitter synthesis (e.g., serotonin and dopamine), which are implicated in mood and appetite regulation.

Several small randomized controlled trials and meta-analyses have examined vitamin B6 supplementation for PMS symptom relief. A 1999 meta-analysis (Am J Obstet Gynecol) concluded that vitamin B6 may be more effective than placebo in relieving overall PMS symptoms, although the quality of evidence was limited by study size and heterogeneity. The doses tested ranged from 50 to 100 mg daily. However, most clinical trials grouped all PMS types together and did not specifically focus on PMS Type C or carbohydrate cravings.

Systematic reviews (e.g., by the Cochrane Collaboration, 2009) found that while some studies show modest benefit, methodological flaws such as small sample sizes, short duration, and inconsistent outcome measures limit the strength of conclusions. There is no clear consensus on the efficacy of vitamin B6 specifically for PMS Type C, but its use is supported to a limited degree by scientific studies addressing general PMS symptoms. Adverse effects are uncommon at recommended doses but can occur with prolonged high intake.

In summary, vitamin B6 has some scientific support for general PMS symptom relief, but the evidence is not robust, particularly for PMS Type C. The rating reflects modest but not definitive validation.

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