Evidence supporting the use of: Vitamin B6 (pyridoxine 5-phosphate)
For the health condition: PMS Type C

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine, especially in its active form pyridoxal 5'-phosphate) has been studied for its potential role in alleviating symptoms of premenstrual syndrome (PMS), including PMS Type C, which is characterized by carbohydrate cravings, headaches, fatigue, and mood swings. The scientific evidence for its use is modest but present, with several clinical trials and reviews suggesting limited efficacy. Proposed mechanisms include B6's involvement in neurotransmitter synthesis (such as serotonin and dopamine), which may influence mood and appetite regulation. Some randomized controlled trials from the 1980s and 1990s reported mild to moderate symptom improvement in women taking B6 supplements (typically 50–100 mg daily), including reductions in mood-related and physical PMS symptoms. However, more recent systematic reviews and meta-analyses (e.g., by the Cochrane Collaboration) have concluded that while there is some evidence for benefit, the quality of studies is variable, and the overall effect size is small. The exact efficacy for PMS Type C specifically (defined by carbohydrate craving and hypoglycemia-like symptoms) is not well established, as most studies have not differentiated between PMS subtypes. Despite these limitations, guidelines in some countries acknowledge B6 as a possible option for PMS symptom management, provided dosing is kept below toxicity thresholds. In summary, Vitamin B6 is used for PMS based on moderate scientific evidence, but its specific effectiveness for PMS Type C remains only partially supported.

More about Vitamin B6 (pyridoxine 5-phosphate)
More about PMS Type C

Products containing Vitamin B6 (pyridoxine 5-phosphate)

We currently have no products on Vitabase that contain this ingredient.