Evidence supporting the use of: Five-leaf Chastetree
For the health condition: PMS Type D
Synopsis
Source of validity: Traditional
Rating (out of 5): 1
Five-leaf Chastetree (Vitex negundo) is traditionally used in some systems of herbal medicine in Asia for a variety of gynecological complaints, including symptoms associated with menstruation such as pain and mood disturbances. However, the majority of research and clinical evidence supporting the use of "chastetree" for premenstrual syndrome (PMS), particularly PMS Type D (characterized by depressive symptoms), is centered on Vitex agnus-castus, commonly known as Chasteberry or Monk’s Pepper, not Vitex negundo. The two species are related but distinct, and their phytochemical profiles differ.
Historical texts in Ayurveda and traditional Chinese medicine describe the use of Five-leaf Chastetree for menstrual regulation and relief of related symptoms, but these references do not specifically address PMS Type D or provide detailed evidence of efficacy. Modern clinical studies examining Vitex negundo for PMS symptoms are lacking, and there is little to no scientific validation supporting its efficacy for this indication. Most references to its use are anecdotal or based in traditional practice, with no direct clinical trials addressing its effect on PMS Type D. Therefore, while its use is rooted in tradition, the level of evidence supporting its benefit for PMS Type D is very low.