Evidence supporting the use of: Vitamin B6 (pyridoxine hydrochloride)
For the health condition: PMS Type D

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine hydrochloride) is used to support or treat PMS Type D, which is characterized by depressive symptoms, based on a mix of scientific studies and longstanding clinical interest. The rationale stems from B6’s role as a cofactor in neurotransmitter synthesis, particularly serotonin and dopamine, which are implicated in mood regulation. Several randomized controlled trials and meta-analyses have examined the efficacy of vitamin B6 supplementation for PMS symptoms, especially mood-related complaints such as irritability, depression, and anxiety. Some studies have reported modest benefits, with doses ranging from 50 mg to 100 mg per day leading to reductions in overall PMS symptoms, including mood disturbances. However, the quality and consistency of these studies vary.

A 1999 meta-analysis by Wyatt et al. (BMJ) suggested that vitamin B6 may be more effective than placebo for PMS symptoms, but noted that methodological limitations and potential publication bias reduce confidence in the findings. More recent systematic reviews have echoed these reservations, pointing to weak or inconsistent evidence, small sample sizes, and varying diagnostic criteria. Guidelines from reputable bodies such as the Royal College of Obstetricians and Gynaecologists mention B6 as a possible option, but emphasize caution regarding dosage due to risk of neuropathy at higher intakes.

In summary, while there is some scientific evidence suggesting a potential benefit of vitamin B6 for PMS Type D, particularly for mood symptoms, the overall quality and strength of the evidence is modest, justifying a rating of 2 out of 5.

More about Vitamin B6 (pyridoxine hydrochloride)
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