Evidence supporting the use of: DIM (diindolylmethane)
For the health condition: PMS Type H

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli and cauliflower. Its use for PMS Type H (Hyperhydration), characterized by bloating and fluid retention, is based on its proposed ability to modulate estrogen metabolism. Scientific interest centers on DIM's role in shifting estrogen metabolism towards the production of less potent metabolites, potentially reducing estrogen dominance symptoms, which may include some PMS symptoms like bloating or breast tenderness. Several small human studies and animal research suggest that DIM can influence estrogen pathways, but direct studies on PMS Type H are lacking. Most clinical trials involving DIM focus on hormone-related conditions such as breast cancer risk or prostate health, rather than PMS subtypes. A few open-label trials and case reports suggest benefits for premenstrual symptoms in general, particularly those linked to estrogen excess. However, robust, placebo-controlled studies examining DIM specifically for PMS Type H are absent. The theoretical rationale remains plausible, and anecdotal reports as well as indirect evidence support its use, but the current scientific evidence is weak and more research is needed to confirm efficacy and safety for this particular PMS subtype. Therefore, while the use of DIM for PMS Type H is grounded in emerging scientific hypotheses, the evidence base is limited and not yet definitive.

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