Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS Type H

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) has been investigated for its role in alleviating symptoms of premenstrual syndrome (PMS), including PMS Type H (Hyperhydration), which is characterized by bloating and fluid retention. The scientific rationale lies in B6's involvement in neurotransmitter synthesis (notably serotonin and dopamine) and its effects on hormonal balance and sodium-water regulation. Several randomized controlled trials and reviews (including a 1999 meta-analysis in BMJ and more recent systematic reviews) have found that Vitamin B6 supplementation, at doses typically ranging from 50 to 100 mg/day, may reduce overall PMS symptoms, particularly mood-related complaints and bloating. However, the evidence is mixed and the quality of studies is variable, with some trials showing benefit and others finding no significant effect compared to placebo. The precise mechanism by which B6 may reduce fluid retention is not fully understood, but it may relate to modulation of aldosterone and estrogen activity, both implicated in fluid balance. Major guidelines (such as those from the Royal College of Obstetricians and Gynaecologists) note B6 as a possible option for PMS symptom relief, but advise caution due to potential neurotoxicity at higher doses. In summary, Vitamin B6 is supported by moderate scientific evidence for use in PMS, with some evidence specifically for symptoms like bloating relevant to PMS Type H, though more rigorous research is needed.

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