Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) is commonly used to support premenstrual syndrome (PMS), particularly PMS Type P, which is characterized by symptoms such as irritability, mood swings, and depression. Several randomized controlled trials and meta-analyses have evaluated the efficacy of Vitamin B6 in alleviating PMS symptoms. The most cited mechanism is Vitamin B6’s role in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology reviewed nine placebo-controlled trials and concluded that Vitamin B6 is likely effective in reducing overall PMS symptoms, especially mood-related symptoms, although the effect size was moderate and some studies had methodological limitations.

More recent reviews corroborate these findings, suggesting that doses between 50-100 mg per day may provide benefit, particularly for psychological symptoms of PMS. However, the strength of evidence is moderate due to small sample sizes, heterogeneity in study designs, and the potential for placebo effects. The use of mixed forms of Vitamin B6 (including pyridoxal, pyridoxine, and pyridoxamine) is not significantly addressed in clinical trials, but standard supplemental forms have been studied. Safety at higher doses is a consideration, as chronic use above 100 mg/day may cause neuropathy.

In summary, the use of Vitamin B6 for PMS Type P has a moderate level of scientific validation, with the best evidence for its effect on mood-related symptoms. More large-scale, high-quality studies are needed to conclusively establish efficacy and safety.

More about Vitamin B6 (Mixed)
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Products containing Vitamin B6 (Mixed)

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