Evidence supporting the use of: Vitamin B6 (pridoxal 5-phosphate)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (in its active form, pyridoxal 5'-phosphate) is commonly used to support or treat symptoms associated with premenstrual syndrome (PMS), particularly PMS Type P, which is characterized by psychological symptoms such as mood swings, irritability, anxiety, and depression. The rationale for its use is based on the role of vitamin B6 in neurotransmitter synthesis, particularly serotonin and dopamine, which are believed to influence mood regulation. Several clinical trials and systematic reviews have explored the effect of vitamin B6 supplementation on PMS symptoms. A 1999 systematic review by Wyatt et al. in the British Medical Journal concluded that vitamin B6 may be effective in reducing PMS symptoms, especially mood-related symptoms, although the quality of the studies was variable and the effect size modest. More recent studies and reviews (e.g., Cochrane reviews) echo that while there appears to be a potential benefit, the evidence is moderate at best due to limitations in study design, small sample sizes, and possible publication bias. Typically, doses of 50-100 mg/day have been used in clinical research, but caution is advised because higher doses can cause neuropathy. In summary, vitamin B6 has some scientific support for use in PMS Type P, with modest evidence primarily for psychological symptoms, but more high-quality research is needed to confirm its efficacy and safety.

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