Evidence supporting the use of: Vitamin B6 (pyridoxal 5 phosphate)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (in its active form, pyridoxal 5'-phosphate) has been studied for its potential to alleviate symptoms of premenstrual syndrome (PMS), including PMS Type P (predominantly psychological symptoms such as mood swings, irritability, and depression). The rationale for its use stems from vitamin B6's role as a cofactor in neurotransmitter synthesis, particularly serotonin and dopamine, which are involved in mood regulation.

Several randomized controlled trials (RCTs) and reviews have assessed vitamin B6 for PMS symptom relief. A 1999 meta-analysis (British Journal of Obstetrics and Gynaecology) of nine placebo-controlled trials concluded that vitamin B6 is more effective than placebo in relieving overall PMS symptoms, especially mood-related symptoms. However, the quality of the studies was generally low, with small sample sizes and methodological limitations.

Subsequent studies have produced mixed results. Some trials report a modest benefit for mood and psychological symptoms, while others show no significant difference compared to placebo. Reviews by authoritative bodies, such as the Cochrane Collaboration, note that while there is some evidence for efficacy, the overall strength of the evidence is moderate at best and further large, high-quality RCTs are needed.

In summary, the use of vitamin B6 for PMS Type P is supported by some scientific evidence, particularly for psychological symptoms, but the quality and consistency of the evidence are moderate. It is not purely traditional; there is scientific rationale and some clinical validation, but not robust or unequivocal support.

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