Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its role in alleviating symptoms of premenstrual syndrome (PMS), particularly PMS Type P (predominantly psychological symptoms such as mood swings, irritability, and depression). The scientific evidence supporting its use is modest but present. Several randomized controlled trials and meta-analyses have assessed the efficacy of vitamin B6 in treating PMS symptoms. For example, a 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology concluded that vitamin B6 is more effective than placebo for relieving overall PMS symptoms, especially mood-related symptoms, with an effect size suggesting a modest benefit. The proposed mechanism involves vitamin B6’s role as a cofactor in the synthesis of neurotransmitters such as serotonin and dopamine, which may influence mood regulation.

However, the quality of the evidence is variable, with some studies being small or having methodological limitations, and later reviews (such as a 2019 Cochrane review) have called for larger, higher-quality trials to confirm efficacy and determine optimal dosing. Safety is another consideration, as doses above 100 mg/day can cause neuropathy. Despite these caveats, vitamin B6 remains one of the few supplements with some scientific backing for PMS, specifically for mood symptoms. Thus, its use is justified by scientific evidence, but the strength of that evidence is moderate (rated 2/5), and treatment should be approached with appropriate caution regarding dosing and expectations.

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