Evidence supporting the use of: Vitamin B6 (pyridoxine hydrochloride)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine hydrochloride) has been investigated as a treatment for premenstrual syndrome (PMS), including PMS Type P (predominantly psychological symptoms such as mood swings, irritability, depression, and anxiety). Several clinical trials and systematic reviews have examined its efficacy. Evidence suggests that Vitamin B6 may help alleviate some psychological symptoms of PMS, possibly due to its role in neurotransmitter synthesis, particularly serotonin and dopamine, which influence mood.

A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology analyzed nine randomized controlled trials and found that Vitamin B6 was more effective than placebo in improving overall PMS symptoms, especially mood-related symptoms. However, the authors noted methodological limitations and small sample sizes. Later reviews, such as a 2013 Cochrane review, concluded that there is some evidence of benefit but emphasized the low quality and heterogeneity of studies.

While Vitamin B6 is commonly recommended and used for PMS, especially for mood symptoms, the overall scientific evidence is modest and not universally conclusive. Most guidelines consider it as a possible option, with caution regarding dosage since high doses can cause neuropathy. In summary, there is some scientific support for Vitamin B6 in treating psychological symptoms of PMS, but the evidence is not strong or definitive, meriting a moderate rating.

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