Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS Type S

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) has been studied for its potential role in alleviating symptoms of premenstrual syndrome (PMS), particularly PMS Type S, which is characterized by symptoms such as irritability, mood swings, anxiety, and depression. PMS Type S ("S" for "Sensitivity") is thought to involve neurotransmitter imbalances, especially serotonin. Vitamin B6 is a coenzyme involved in the biosynthesis of neurotransmitters, including serotonin and dopamine, which provides a scientific rationale for its use in this context.

Multiple randomized controlled trials and meta-analyses have investigated the efficacy of vitamin B6 supplementation for PMS symptoms. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology reviewed nine placebo-controlled trials and concluded that vitamin B6 may be effective in treating PMS symptoms, notably emotional symptoms, although the studies were of variable quality. Dosages in studies typically range from 50 to 100 mg daily. The Cochrane Database of Systematic Reviews (2003) also found some evidence of benefit but noted methodological limitations and potential for bias.

Overall, the evidence supporting vitamin B6 for PMS Type S is moderate. While there is a plausible biological mechanism and some clinical trial data suggest benefit, the quality of the evidence is limited by small sample sizes and methodological concerns. Thus, vitamin B6 is considered a scientifically supported, though not definitively proven, option for PMS Type S, warranting a mid-level evidence rating.

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