Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: PMS Type S

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in managing premenstrual syndrome (PMS), including PMS Type S, which is associated primarily with symptoms of sugar craving and mood changes due to suspected neurotransmitter imbalances. The rationale for using vitamin B6 relates to its involvement in the synthesis of neurotransmitters such as serotonin and dopamine, which are implicated in mood regulation. Several clinical studies and reviews have evaluated the efficacy of vitamin B6 for PMS symptoms. Some randomized controlled trials have shown modest benefits of vitamin B6 supplementation (typically in doses of 50-100 mg per day) in reducing overall PMS symptoms, especially mood-related complaints such as irritability, depression, and fatigue. However, the quality of evidence is mixed: many studies are small, have methodological limitations, or use subjective outcome measures. Meta-analyses, such as the Cochrane review (Wyatt et al., 1999; updated 2009), conclude that vitamin B6 may be more effective than placebo, but the effect size is small and there is moderate risk of bias. Specifically for PMS Type S, direct evidence is limited, but because mood symptoms and cravings are prominent, the theoretical basis for B6 is plausible. Nevertheless, due to inconsistent findings and methodological issues, the evidence is best characterized as low to moderate quality. Current guidelines sometimes suggest a trial of B6 for PMS, but emphasize caution due to potential neurotoxicity at higher doses and the need for further research.

More about Vitamin B6 (pyridoxine)
More about PMS Type S

Products containing Vitamin B6 (pyridoxine)

We currently have no products on Vitabase that contain this ingredient.