Evidence supporting the use of: Tetrahydrocannabinol
For the health condition: Post Traumatic Stress Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, has been explored as a treatment for Post Traumatic Stress Disorder (PTSD) primarily in recent years. The rationale for its use is rooted in the understanding that the endocannabinoid system, which THC activates, is involved in processes such as memory, fear extinction, and emotional regulation—key factors implicated in PTSD pathology. Early case reports and small observational studies have suggested that cannabis, including THC-rich preparations, may help some individuals with PTSD by reducing symptoms like nightmares, insomnia, and hyperarousal.

However, the scientific evidence remains limited and mixed. Randomized controlled trials (RCTs) are rare, and most published studies are small, short-term, or have methodological limitations. Some studies report modest improvements in PTSD symptoms, while others highlight increased risks, such as dependence, cognitive impairment, or worsening anxiety in some patients. Systematic reviews generally conclude that there is insufficient high-quality evidence to recommend THC as a standard treatment for PTSD, though ongoing research may clarify its role. Major organizations, such as the American Psychiatric Association, do not currently endorse THC or cannabis for PTSD due to these uncertainties.

In summary, while there is some scientific rationale and preliminary evidence for THC’s use in PTSD, the overall quality and quantity of supporting data is low, justifying a moderate-low evidence rating.

More about Tetrahydrocannabinol
More about Post Traumatic Stress Disorder

Products containing Tetrahydrocannabinol

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