False Unicorn (Chamaelirium luteum) has a long history of use in traditional North American herbal medicine, particularly by Indigenous peoples and later by 19th-century eclectic physicians. It was commonly included in herbal formulas aimed at supporting women's reproductive health, including fertility and various issues related to pregnancy, such as threatened miscarriage and “uterine weakness.” Traditional herbalists have used false unicorn root in attempts to "tone" the uterus and promote a healthy pregnancy, though the specific mechanisms were not scientifically understood.

Despite this historical use, there is a lack of robust clinical or scientific evidence to support its efficacy or safety for pregnancy-related conditions. The available information is primarily anecdotal or based on traditional herbal texts. No well-designed clinical trials or pharmacological studies have validated its use for supporting pregnancy, and its safety profile during pregnancy is not established. Modern herbalists sometimes caution against its use during pregnancy due to insufficient safety data. Therefore, its use is supported by tradition rather than scientific validation, and the overall evidence is weak.