Evidence supporting the use of: Vitamin B12 (adenosylcobalamin)
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12 (adenosylcobalamin, along with other active forms such as methylcobalamin) plays a crucial role in pregnancy, and its use is scientifically validated. B12 is essential for DNA synthesis, red blood cell formation, and neurological function. During pregnancy, maternal B12 requirements increase to support fetal growth and neurological development. Deficiency in B12 during pregnancy is associated with an increased risk of neural tube defects, preterm birth, low birth weight, and impaired cognitive development in the infant (O'Leary & Samman, 2010).

Clinical guidelines recommend that pregnant women, especially those following vegetarian or vegan diets (where B12 intake may be low), ensure adequate B12 intake through diet or supplementation. Randomized controlled trials and observational studies have demonstrated that supplementation corrects deficiency and improves maternal and neonatal outcomes in at-risk populations (Koebnick et al., 2004).

While B12 is not an "herb," it is commonly included in prenatal vitamins and supplements. There is little historical or traditional use specifically of B12 supplements in pregnancy, as the vitamin was only isolated and understood in the 20th century. The scientific rationale for its use is strong, and it is an evidence-based recommendation in modern prenatal care.

More about Vitamin B12 (adenosylcobalamin)
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