Evidence supporting the use of: Vitamin B6 (pyridoxal 5 phosphate)
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate, is supported by scientific evidence for use in pregnancy, mainly for the management of nausea and vomiting (morning sickness). Several randomized controlled trials and systematic reviews have demonstrated that vitamin B6 supplementation can reduce the severity and frequency of nausea in pregnant women, especially in the first trimester. The American College of Obstetricians and Gynecologists (ACOG) recommends vitamin B6 as a first-line therapy for mild to moderate nausea and vomiting in pregnancy. Typical doses studied range from 10 to 25 mg, taken three times daily. The mechanism is not fully understood, but B6 is involved in neurotransmitter synthesis and may affect pathways associated with nausea.

There is less evidence supporting broader uses of vitamin B6 in pregnancy beyond nausea and vomiting; for example, its use for preventing miscarriage or other complications is not established. However, B6 is considered safe in moderate doses during pregnancy and is an essential nutrient for fetal development. Excessive intake, however, has potential risks and should be avoided. Overall, the evidence supporting vitamin B6 for morning sickness is strong, with high-quality studies and guideline endorsements, justifying a high evidence rating.

More about Vitamin B6 (pyridoxal 5 phosphate)
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