Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6 (pyridoxine) is most commonly used during pregnancy to help manage nausea and vomiting, often referred to as "morning sickness." There is substantial scientific evidence supporting its efficacy for this purpose. Randomized controlled trials and systematic reviews have demonstrated that Vitamin B6 supplementation can significantly reduce the severity of nausea in pregnant women compared to placebo, with a favorable safety profile when used at recommended doses. For example, a well-known double-blind trial published in the American Journal of Obstetrics and Gynecology (1991) found that women taking 25 mg of pyridoxine three times daily experienced a notable reduction in nausea symptoms. Additionally, clinical guidelines, such as those from the American College of Obstetricians and Gynecologists (ACOG), recommend Vitamin B6 as a first-line treatment for pregnancy-related nausea and vomiting.

While Vitamin B6 is sometimes discussed for other pregnancy-related uses, such as supporting fetal development, its primary validated use is for controlling nausea and vomiting. The historical use of Vitamin B6 in pregnancy is less prominent compared to its scientific validation, as its popularity for this purpose arose mainly after clinical studies were conducted in the latter half of the 20th century. Overall, Vitamin B6 is widely regarded as a safe and effective intervention for mild-to-moderate morning sickness in pregnant women.

More about Vitamin B6 (pyridoxine)
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