Evidence supporting the use of: Vitamin B9 (methyltetrahydrofolate)
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B9, particularly in its active form as methyltetrahydrofolate (5-MTHF), has strong scientific validation for use in pregnancy. Folate is essential for DNA synthesis, repair, and methylation, processes that are critical during periods of rapid cell division and growth, such as pregnancy. Adequate folate intake before conception and during early pregnancy is conclusively linked to a reduced risk of neural tube defects (NTDs) such as spina bifida and anencephaly in the developing fetus. This evidence has been established by numerous large-scale epidemiological studies and randomized controlled trials.

Because some individuals have genetic polymorphisms (such as MTHFR mutations) that reduce the ability to convert folic acid to its active form, 5-MTHF supplementation may offer an advantage for these populations by bypassing this metabolic step. This is particularly relevant in prenatal supplementation, as it ensures that the biologically active form of folate is available. Health authorities such as the CDC, WHO, and major obstetric organizations strongly recommend folate supplementation for women of childbearing age, with many prenatal supplements now containing 5-MTHF as an alternative to folic acid.

In summary, the use of methyltetrahydrofolate in pregnancy is strongly supported by scientific evidence for the prevention of neural tube defects and for supporting healthy fetal development.

More about Vitamin B9 (methyltetrahydrofolate)
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