Evidence supporting the use of: Five-leaf Chastetree
For the body system: Progesterone

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Five-leaf Chastetree (Vitex negundo) is often confused with Vitex agnus-castus (Chaste Tree or Chasteberry), which has more substantial research regarding support of the progesterone body system. However, Vitex negundo has a long history of traditional use in Ayurvedic and folk medicine for various ailments, but scientific investigations into its effects on the hormonal system, specifically progesterone, are limited. Some preliminary animal studies suggest that extracts of Vitex negundo may influence female reproductive hormones, including modulation of the luteinizing hormone and follicle-stimulating hormone, which can indirectly affect progesterone levels. However, these findings are not yet robust or well-established in human clinical trials. In comparison, Vitex agnus-castus has clearer evidence supporting its use to modulate progesterone by acting on the pituitary gland to increase luteinizing hormone, thereby promoting progesterone production. For Vitex negundo, the current scientific evidence supporting its use for direct progesterone support is moderate at best, meriting a score of 3. More rigorous human studies are needed to confirm efficacy and mechanisms. It is important to ensure the correct botanical is referenced, as misidentification between V. negundo and V. agnus-castus is common in herbal literature and supplements.

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