Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitexicarpin, also known as casticin, is a flavonoid compound found primarily in the fruit of Vitex agnus-castus (chaste tree). The use of chaste tree extracts (which contain Vitexicarpin) to support the progesterone body system and balance female hormones is largely based on traditional herbal medicine practices, especially in Europe and the Mediterranean. Historically, Vitex agnus-castus has been used to address menstrual irregularities, premenstrual syndrome (PMS), and other gynecological complaints thought to be related to hormonal imbalance.

Modern research regarding Vitexicarpin itself is limited; most studies focus on the whole extract rather than the isolated compound. Some clinical studies of chaste tree extract suggest it may influence the hypothalamic-pituitary-gonadal axis, potentially leading to increased luteinizing hormone (LH) and subsequent progesterone production. However, direct evidence that Vitexicarpin alone supports the progesterone system is lacking, and the mechanism of action remains unclear. Thus, while the traditional use is well-documented, scientific validation, particularly for Vitexicarpin as a single molecule, is insufficient.

In summary, Vitexicarpin’s link to progesterone support is primarily justified by traditional use of its source plant, and there is only limited, indirect scientific support for its efficacy in this context.

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