Evidence supporting the use of: Arachidonic acid
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Arachidonic acid (AA) is a polyunsaturated omega-6 fatty acid that plays a pivotal role in the body's biochemistry, particularly as a direct precursor to prostaglandins, which are a class of lipid compounds involved in inflammation, immune modulation, and other physiological functions. The pathway begins with AA being released from membrane phospholipids by phospholipase A2 and subsequently converted by cyclooxygenase (COX) enzymes into various prostaglandins (such as PGE2, PGD2, and PGF2α), as well as thromboxanes and leukotrienes through other enzymatic routes.

There is robust scientific validation for AA's role as a foundational substrate for prostaglandin synthesis. Numerous studies have mapped out this biochemical pathway and demonstrated that dietary or supplemental AA can increase tissue levels of prostaglandins under certain conditions. Clinical trials and animal studies have confirmed that modulating AA intake can influence prostaglandin-mediated processes, such as inflammation, fever, and platelet aggregation. However, it is also well established that excessive AA or its metabolites can promote pro-inflammatory states, so its supplementation is typically approached with caution in clinical contexts.

In summary, the use of arachidonic acid to support the prostaglandin system is justified by strong scientific evidence. Its supplementation is not universally recommended, but its central role in prostaglandin biosynthesis is well-documented in the scientific literature.

More about arachidonic acid
More about Prostaglandins

Other body systems supported by arachidonic acid

Blood
Brain
Immune System
Muscles
Nerves
Prostaglandins
Reproductive System
Skin

Products containing arachidonic acid

We currently have no products on Vitabase that contain this ingredient.