Evidence supporting the use of: DHA
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Docosahexaenoic acid (DHA) is an omega-3 fatty acid well-studied for its roles in human health, including its impact on the prostaglandin system. Prostaglandins are lipid compounds derived from fatty acids that play key roles in inflammation, vascular tone, and other physiological functions. DHA serves as a precursor to anti-inflammatory eicosanoids and specialized pro-resolving mediators, and its incorporation into cell membranes can alter the availability of arachidonic acid—the primary substrate for pro-inflammatory prostaglandin synthesis.

Several human and animal studies demonstrate that increased dietary DHA leads to changes in the types and amounts of prostaglandins produced by tissues, generally resulting in a shift toward less inflammatory profiles. For example, DHA can decrease the production of pro-inflammatory prostaglandin E2 (PGE2) derived from arachidonic acid, while increasing the formation of less inflammatory prostaglandins and resolvins. These effects are observed in contexts such as cardiovascular health, inflammatory conditions, and neuroinflammation.

The scientific consensus, based on reviews and meta-analyses, supports the notion that DHA modulates the prostaglandin system primarily by competing with arachidonic acid and by generating its own series of bioactive lipid mediators. However, the clinical implications of these biochemical effects still require further large-scale, targeted research. Overall, there is strong biochemical and mechanistic evidence for DHA's influence on the prostaglandin system, justifying its use for this purpose.

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