Evidence supporting the use of: Fish roe oil
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fish roe oil is primarily valued for its rich content of omega-3 polyunsaturated fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Omega-3 fatty acids are precursors to a group of signaling molecules, including certain prostaglandins, which are involved in regulating inflammation and other physiological processes. Scientific research has demonstrated that EPA and DHA can modulate the production of prostaglandins and related eicosanoids, generally promoting the formation of anti-inflammatory prostaglandins (such as PGE3) while reducing pro-inflammatory prostaglandins derived from arachidonic acid (such as PGE2).

Several in vitro and animal studies, as well as some clinical trials, have suggested that consuming omega-3-rich oils—including fish roe oil—can influence prostaglandin synthesis pathways, leading to a more balanced inflammatory response. However, most of these studies have focused on fish oil in general rather than specifically on fish roe oil, though fish roe oil is chemically similar and contains high levels of EPA and DHA.

While there is scientific plausibility and some supporting evidence for the use of fish roe oil in modulating prostaglandin-mediated processes, the body of direct clinical evidence is limited. Therefore, the evidence rating is moderate (3/5), reflecting reasonable support from biochemical studies and indirect evidence, but lacking in large-scale, targeted clinical trials specific to fish roe oil and prostaglandin modulation.

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