Evidence supporting the use of: Gamma-linolenic acid
For the body system: Prostaglandins

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in plant oils such as evening primrose oil and borage oil. Its use to support the prostaglandin system is rooted in scientific understanding of fatty acid metabolism. GLA is a precursor to dihomo-gamma-linolenic acid (DGLA), which is subsequently converted into series-1 prostaglandins (such as PGE1) via the cyclooxygenase pathway. These prostaglandins are associated with anti-inflammatory and regulatory effects in the body.

Several clinical and preclinical studies have investigated the effects of GLA supplementation on conditions related to prostaglandin imbalances, such as atopic dermatitis, rheumatoid arthritis, and premenstrual syndrome. Results have been mixed, with some showing modest benefits and others finding little to no significant effect. The mechanism by which GLA could exert beneficial effects is scientifically plausible, as increased intake may help modulate the balance of pro- and anti-inflammatory prostaglandins, particularly in individuals with impaired endogenous conversion of linoleic acid to GLA.

Overall, the use of GLA to support the prostaglandin system is grounded in biochemistry and has some supportive, albeit inconsistent, evidence from clinical research. The evidence is not robust enough for universal endorsement but is sufficient to rate the scientific support as moderate.

More about Gamma-linolenic acid
More about Prostaglandins

Products containing Gamma-linolenic acid

We currently have no products on Vitabase that contain this ingredient.