Evidence supporting the use of: Omega-3
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are scientifically validated to influence the prostaglandin pathway in the body. Prostaglandins are lipid compounds that perform hormone-like functions, including regulation of inflammation, blood flow, and the formation of blood clots. They are synthesized from fatty acids, most notably arachidonic acid (an omega-6 fatty acid) and eicosapentaenoic acid (an omega-3 fatty acid).

Numerous studies have demonstrated that omega-3 fatty acids can shift the balance of prostaglandin production toward less inflammatory types. EPA competes with arachidonic acid for the same enzymes (cyclooxygenase and lipoxygenase), resulting in the production of prostaglandins and leukotrienes that are less potent mediators of inflammation. This has clinical relevance in conditions such as cardiovascular disease, rheumatoid arthritis, and other chronic inflammatory disorders.

Reviews and meta-analyses published in peer-reviewed journals (e.g., American Journal of Clinical Nutrition, Journal of Lipid Research) confirm that dietary supplementation with omega-3 fatty acids leads to measurable changes in the fatty acid composition of cell membranes and alters the profile of prostaglandins and other eicosanoids produced. While not all prostaglandin-mediated effects are fully understood, the impact of omega-3s on prostaglandin synthesis is well established in scientific literature.

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