Evidence supporting the use of: Diindolylmethane
For the body system: Prostate

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed during the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli and Brussels sprouts. Its use for prostate health is based on its influence on estrogen metabolism. Some laboratory and animal studies have suggested that DIM can modulate estrogen activity, supporting a healthier balance of estrogen metabolites. This is relevant because certain estrogen metabolites are thought to influence prostate tissue growth and may play a role in prostate health and disease.

Small-scale human clinical studies have investigated DIM supplementation for men with prostate issues, such as prostate cancer or benign prostatic hyperplasia (BPH). Results indicate that DIM may have mild anti-androgenic effects and could influence prostate-specific antigen (PSA) levels, but findings are preliminary and not universally consistent. DIM has also been shown to have anti-inflammatory and potential anti-cancer properties in laboratory settings, which are of interest for prostate health. However, large, well-controlled clinical trials in humans are lacking.

In summary, there is a scientific rationale and some early research supporting DIM's potential role in prostate health, but the overall quality and quantity of evidence is limited. Therefore, DIM's use for supporting the prostate is based on preliminary scientific evidence rather than robust clinical validation.

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