Evidence supporting the use of: EGCG
For the body system: Prostate

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG) is a major catechin found in green tea and has been investigated for its potential role in supporting prostate health. Several preclinical studies suggest that EGCG may inhibit the growth of prostate cancer cells in vitro and in animal models. Proposed mechanisms include the induction of apoptosis (programmed cell death), inhibition of cell proliferation, and suppression of androgen receptor signaling, which is relevant to prostate cancer progression. Some human observational studies and small clinical trials have examined the potential of green tea extracts (rich in EGCG) to reduce prostate-specific antigen (PSA) levels or slow the progression of prostate lesions, though results are mixed and often not statistically significant. A 2012 meta-analysis found some evidence for a protective effect of green tea consumption against prostate cancer risk, but the effect size was modest and not always consistent across studies. Overall, while there is promising preclinical evidence, clinical data supporting the use of EGCG specifically for prostate health remain limited and inconclusive. EGCG is not traditionally used for prostate health, but its application is supported by a growing, though still preliminary, body of scientific literature. Larger and more rigorous human studies are needed to establish its efficacy and safety for this purpose.

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Products containing EGCG

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