Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Equol is a metabolite produced by intestinal bacteria from the isoflavone daidzein, which is found in soy. It has gained attention for its potential role in supporting prostate health, particularly in relation to benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in men. Several scientific studies suggest that equol, especially the S-equol enantiomer, may exert beneficial effects on the prostate by modulating androgen signaling, notably by binding to dihydrotestosterone (DHT), a hormone implicated in prostate enlargement. This binding may reduce DHT activity and thus help manage prostate growth. Randomized controlled trials and observational studies have demonstrated that supplementation with S-equol can improve urinary symptoms associated with BPH. For example, a double-blind, placebo-controlled study published in the journal Urology (2012) found that S-equol supplementation improved International Prostate Symptom Scores (IPSS) in Japanese men. Additionally, epidemiological data indicate that populations with higher soy intake—and thus greater likelihood of equol production—have lower rates of prostate problems. However, not all individuals naturally produce equol, and the efficacy of supplementation may vary. While preliminary and mid-stage clinical evidence is promising, large-scale, long-term studies are still limited. In summary, there is a reasonable scientific basis for using equol to support prostate health, warranting an evidence rating of 3 out of 5.

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