Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Genistein is an isoflavone found primarily in soy products and has been studied for its potential effects on prostate health. Several laboratory and animal studies suggest that genistein may have anti-cancer properties, especially in relation to prostate cancer. The proposed mechanisms include inhibition of cell proliferation, induction of apoptosis, and modulation of hormone pathways (estrogenic and anti-androgenic effects). Some epidemiological studies have shown lower rates of prostate cancer in populations with high dietary intake of soy isoflavones, which includes genistein.

However, clinical evidence in humans is limited and somewhat inconsistent. A few small-scale clinical trials have examined genistein supplementation or soy isoflavone intake in men with prostate cancer or at risk of developing it. These studies generally show modest benefits, such as decreased prostate-specific antigen (PSA) levels or slowed progression of prostate cancer biomarkers, but results are not robust or universally replicated.

There is not enough high-quality, large-scale evidence to conclusively recommend genistein as a primary supplement for prostate health. Its use is based on a plausible scientific rationale and preliminary data, but more rigorous human studies are needed. Therefore, while genistein is sometimes included in prostate health supplements and has some scientific basis, the overall level of evidence supporting its use is currently modest.

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