Evidence supporting the use of: Isothiocyanates
For the body system: Prostate

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isothiocyanates are biologically active compounds found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. The most studied isothiocyanate, sulforaphane, has attracted scientific interest for its potential protective effects on the prostate. Preclinical studies suggest that isothiocyanates can inhibit the growth of prostate cancer cells through mechanisms including modulation of phase II detoxification enzymes, induction of apoptosis, and inhibition of androgen receptor signaling. Epidemiological studies have reported an association between higher consumption of cruciferous vegetables and a reduced risk of prostate cancer, though these findings are not entirely consistent and causality has not been definitively established.

A few small clinical trials have explored the effects of isothiocyanate-rich foods or extracts on prostate health. For example, some studies have found that broccoli sprout extracts can alter gene expression in the prostate and may reduce biomarkers of cancer progression in men with prostate cancer or high-grade prostatic intraepithelial neoplasia. However, these studies are limited in size and duration, and more robust randomized controlled trials are needed to confirm clinical benefits. Overall, there is moderate scientific evidence supporting isothiocyanates for prostate health, primarily based on laboratory and observational data, with emerging but preliminary support from human trials.

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