Evidence supporting the use of: Nettle (unspecified)
For the body system: Prostate

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nettle (Urtica dioica), particularly its root, has been traditionally used and is scientifically investigated for supporting prostate health, especially in the context of benign prostatic hyperplasia (BPH). Several clinical studies and reviews have evaluated the efficacy of nettle root extracts in men with lower urinary tract symptoms (LUTS) associated with BPH. The mechanism is thought to involve inhibition of the binding of sex hormone-binding globulin, interference with aromatase activity, and anti-inflammatory effects, though exact pathways remain under investigation.

Randomized controlled trials, such as those published in Phytomedicine (2005) and reviewed in the journal Urologia Internationalis (2013), have demonstrated that nettle root extract can significantly improve urinary flow and reduce symptoms compared to placebo. However, it is typically used as part of combination phytotherapy (e.g., with saw palmetto). The European Medicines Agency (EMA) recognizes traditional use of nettle root for relief of urinary symptoms related to BPH, although it also notes that evidence from large, high-quality trials is limited.

In summary, nettle root shows a moderate level of scientific validation for supporting the prostate, particularly in BPH, but more robust, high-quality research is needed to definitively establish its efficacy and mechanism.

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